China (Mainland)
High purity Agomelatine with best price and good quality CAS NO.138112-76-2 CAS NO.138112-76-2
- FOB Price: USD: 1,900.00-2,000.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
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- Product Details
Keywords
- high quality Agomelatine
- Best price of nootropicsCOLINE
- 138112-76-2
Quick Details
- ProName: High purity Agomelatine with best pric...
- CasNo: 138112-76-2
- Molecular Formula: C15H17NO2
- Appearance: white powder
- Application: medical intermediate
- DeliveryTime: 3-15 working days
- PackAge: aluminium foil bag
- Port: any port in China
- ProductionCapacity: 1000 Kilogram/Week
- Purity: 99%
- Storage: dry and cool place
- Transportation: by air or boat
- LimitNum: 1 Kilogram
- Moisture Content: 0
- Impurity: 0
- 0: 0
Superiority
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1, Rich Experience in produce----We have 26 years experiences in chemical products and 6years experiences in Pharmaceutical Intermediate products and APIS.
2, Competitive price ---We have the competitive price owing to low labor cos,t(we need large quantity).
3, Stable supply ability ---We have a stable supply ability owing to three workshops produce plan every month and stock plan for each products ;
4, Shipment Timely---The shipment never delayed and we can get reorder from new customer;
5, Rich experience in sales-- We have rich experience working with large international company.
6, Strong Quality Control System ---We have a very strong quality control system Raw material control / process control/ finished product quality inspection.
7. We Supply the Technology Support for Analyze and Synthesis and do new product according to customer's requirement.
8. Accept third lab test---We accept audit directly and tested . No any risk commitment for Customers.
9.Various payment terms---We can accept various payment terms include TT, and so on.
10,Our service---Free sample and 24 hours on-line professional service and other requirements
Agomelatine Basic Info:
Name:Agomelatine
CAS Number:138112-76-2
Formula:C15H17NO2
Molecular Weight:243.30098
Synonyms:Thymanax;N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;S 20098;Valdoxan;Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-;
Density:1.109 g/cm3
Melting Point:107-109 °C
Boiling Point:478.8 °C at 760 mmHg
Flash Point:243.4 °C
Specification: 99% by HPLC
| Item | Specifications | Results |
| Assay(HPLC) | 98.0%~102.0% | 98.9% |
| Appearance | Off-white powder | Complies |
| Identification | IR | Complies |
| Melting point | 156.0~160.0℃ | 157.0~158.0℃ |
| Loss on drying | ≤0.5% | 0.11% |
| Residue on ignition | ≤0.1% | 0.06% |
| Related substance | ≤1.0% | 0.75% |
| Heavy metals | ≤10ppm | Complies |
Details
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1)Product Name:Natural Nootropics Agomelatine powder CAS 138112-76-2
2)Purity:99%
3)Testing Method:HPLC
4)Molecular Formula:C15H17NO2
5)Introduction:
Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively.
Agomelatine is one kind of off-white or white crystalline powder or white solid. The IUPAC Name of this chemical is N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide. This chemical belongs to Aromatics Compounds;Aromatics;Neurochemicals;APIS. It should be store at -20°C Freezer. Agomelatine Solubility: Soluble in Chloroform and Methanol. DMSO ≥49mg/mL Water <1mg/mL Ethanol ≥49mg/mL.
As a Pharmaceutical Intermediates, Agomelatine is used in the treatment of major depressive disorder, emotional disorder. Agomelatine is used in the treatment of major depressive disorder, emotional disorder. The drug substance for Nervous system. Antidepressant, anxiolytic, adjusting the rhythm of sleep and regulating biological clock. Agomelatine is a melatoninergic agonist and selective antagonist of 5-ht2c receptors. Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.
Certification of Analysis
|
ITEM |
STANDARD |
RESULTS |
|
Appearance |
White to almost white crystalline powder |
white crystalline powder |
|
Solubility |
This product is soluble in DMF, methanol, ethanol, water and 0.1mol/L hydrochloric acid solution almost not |
108.4-108.5 C |
|
UV |
Has an absorption maximum at 230nm |
Conforms |
|
IR |
Corresponding to reference spectrum |
Conforms |
|
Chloride |
≤0.01% |
Conforms |
|
Single impurity |
≤0.5% |
0.049% |
|
Total impurity |
≤0.1% |
0.06% |
|
Impurities I |
≤0.1% |
Not detected |
|
Impurities II |
≤0.1% |
Not detected |
|
N-hexane |
≤0.029% |
0.0002% |
|
Ethanol |
≤0.5% |
0.1% |
|
Dichloromethane |
≤0.06% |
Not detected |
|
Ethyl acetate |
≤0.5% |
Not detected |
|
Tetrahydrofuran |
≤0.072% |
Not detected |
|
Toluene |
≤0.089% |
Not detected |
|
Chloroform |
≤0.006% |
0.001% |
|
Loss on drying |
≤0.5% |
0.002% |
|
Residue on ignition |
≤0.1% |
0.06% |
|
Heavy metal |
≤20ppm |
Conforms |
|
Assay |
≥99.0% |
99.52% |
|
Conclusion |
Qualified |
|
Function&Application
Agomelatine can help regulate your'body clock' (circadian rhythm) with positive benefits on mood and sleepin depression Agomelatine is used in the treatment of depression or to help prevent depression returning, and isonly available with a doctor's prescription. The symptoms of depression vary from one person toanother, but commonly include persistent sadness, loss of interest in favourite activities, feelings of worthlessness, sleep problems, feeling of being slowed down, feelings of anxiety or changes in appetite and weight. Changes in your daily sleep and appetite patterns are examples of disturbances of your body clock that occur commonly indepression.
Product information
| AGOMELATINE Basic information |
| Antidepressants Health risk Patent cases Application |
| Product Name: | AGOMELATINE |
| Synonyms: | AGOMELATINE;n-(2-(7-methoxy-1-naphthalenyl)ethyl)-acetamid;n-(2-(7-methoxy-1-naphthalenyl)ethyl)acetamide;n-(2-(7-methoxynaphth-1-yl)ethyl)acetamide;S20098,N-[2-(7-Methoxynaphth-1-yl)ethyl]acetamide;S 20098;AGOMELATIN;Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)- |
| CAS: | 138112-76-2 |
| MF: | C15H17NO2 |
| MW: | 243.30098 |
| EINECS: | |
| Product Categories: | Aromatics Compounds;Aromatics;Neurochemicals;APIS;API;Agomelatine;Valdoxan, Melitor, Thymanax |
| Mol File: | 138112-76-2.mol |
| AGOMELATINE Chemical Properties |
| mp | 107-109°C |
| storage temp. | -20°C Freezer |
| CAS DataBase Reference | 138112-76-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | N |
| Risk Statements | 50 |
| Safety Statements | 61 |
| AGOMELATINE Usage And Synthesis |
| Antidepressants | Agomelatine, which is developed by the French Servier company, is the world's first melatonin receptors MT1 and MT2 agonist class of antidepressants. It applies to the treatment of adult patients with severe depressive. We know that melatonin is an endogenous neural hormones. It is only produced by the pineal gland anterior pituitary at night, and acts on the melatonin receptor that focuses on the presence of hypothalamic suprachiasmatic nucleus (SCN). It is involved in mediating the circadian rhythms in mammals. It is the well-known time guardian in the body, which can regulate the biological clock that is modulated by external circadian cycle. However, since that melatonin has high catabolism rate in vivo which mikes its half-life shorter and the selectivity of its receptor located in the SCN poorer, the treatment of circadian rhythms disorders is limited. Therefore, in order to overcome these drawbacks of melatonin, the researchers designed a series of melatonin analogues. Molecular modeling studies have shown that indole ring of melatonin is the structure sites of catabolic inactivation. Indole ring is an ideal site of isosteric modifications. Agomelatine developed by Servier company is melatonin’s naphthalene biological (electronic) isostere analogs. Indole ring is substituted by naphthalene nucleus, which leads it have more metabolic stability than melatonin. |
| Pharmacological effects | The listing of agomelatine is a new breakthrough in the field of the treatment of depression. It is melatonin MT1 / MT2 receptor agonist and serotonin 2c (5-HT2C) receptor antagonist. It can make depressed patients’ biological rhythm disorders return to normal through the synergy between the two and then result in antidepressant efficacy. Its unique mechanism of action has opened up an innovative way to treat depression. Agomelatine’s mechanism of drug action is completely different with antidepressants that are commonly used today, such as selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI). SSRI and SNRI antidepressants achieve antidepressant efficacy by increasing concentration of serotonin. But it also brings a lot of side effects, such as weight changes, sexual dysfunction, withdrawal syndrome and the like. The molecular structure of agomelatine directly combines with serotonin 2c (5HT2c) receptor of post-synaptic membrane so as to exert its antidepressant efficacy without increasing serotonin concentration in the synaptic cleft. This unique mechanism of action makes agomelatine quickly and effectively exert its antidepressant efficacy at the same time, and avoid the occurrence of adverse drug reactions to an extreme. Another unique targets of agomelatine is in melatonin receptors. MT1 and MT2 receptors densely distribute in the human suprachiasmatic nucleus. The nucleus mainly control human sleep rhythm. Agomelatine can well improve the quality of patients’ sleep by agonism on MT1 MT2 receptors, and improve patients’ wakefulness during the day. The quality of sleep has both cause and effect relationship with depression outcomes state. It is reported that 80% of patients with depression have the problems of sleep disorders at different levels. The improvement of sleep quality can directly contribute to the improvement of the overall clinical condition of patients with depression. The above information is edited by the Chemicalbook of Ge Qian. |
| Health risk | October 30, 2012, the British Medicines and Healthcare Products Agency (MHRA) released agomelatine (agomelatine, Valdoxan/Thymanax) security information. MHRA found that several cases appears serious reports of liver toxicity with agomelatine, including six cases of liver failure patients within worldwide report. Agomelatine's drug information already includes in the recommendations that all patients need liver function tests at the start of treatment and during treatment. Now liver function tests should also be recommended when the drug dose is increased. MHRA recommends that if the patients have potential liver damage symptoms or signs, or that the increases of serum transaminase beyond the upper limit of normal (ULN) three times is found in the function tests, it should be immediately suspended. |
| Patent cases | The earliest agomelatine compound patent is French Patent FR902393, which is applied in February 27, 1990. This patent has the same patent family in Europe, USA, Canada, Japan and Australia. But there is no Chinese patent. The above patents were all authorized after January 1, 1993. Therefore China is also ineligible for administrative protection. Agomelatine has both technology patent and polymorph patent in China. But it also can be avoided. |
| Application | Melatonin drugs. |
| Chemical Properties | White Solid |
| Usage | Agomelatine is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of |
| Usage | Agomelatine is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C receptors, respectively. |
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Package:20Kg Paper box or 25kg Paper barrel
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