Best Sarms Series 99% Purity GW0742 CAS NO.317318-84-6 CAS NO.317318-84-6
- FOB Price: USD: 1,900.00-2,000.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
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- Product Details
Keywords
- GW0742 powder
- Best price of GW0742
- 317318-84-6
Quick Details
- ProName: Best Sarms Series 99% Purity GW0742 CA...
- CasNo: 317318-84-6
- Molecular Formula: C21H17F4NO3S2
- Appearance: white powder
- Application: medical intermediate
- DeliveryTime: 3-15 working days
- PackAge: aluminium foil bag
- Port: any port in China
- ProductionCapacity: 1000 Kilogram/Week
- Purity: 99%
- Storage: dry and cool place
- Transportation: by air or boat
- LimitNum: 1 Kilogram
- Moisture Content: 0
- Impurity: 0
- 0: 0
Superiority
Our advantages
1, Rich Experience in produce----We have 26 years experiences in chemical products and 6years experiences in Pharmaceutical Intermediate products and APIS.
2, Competitive price ---We have the competitive price owing to low labor cos,t(we need large quantity).
3, Stable supply ability ---We have a stable supply ability owing to three workshops produce plan every month and stock plan for each products ;
4, Shipment Timely---The shipment never delayed and we can get reorder from new customer;
5, Rich experience in sales-- We have rich experience working with large international company.
6, Strong Quality Control System ---We have a very strong quality control system Raw material control / process control/ finished product quality inspection.
7. We Supply the Technology Support for Analyze and Synthesis and do new product according to customer's requirement.
8. Accept third lab test---We accept audit directly and tested . No any risk commitment for Customers.
9.Various payment terms---We can accept various payment terms include TT, and so on.
10,Our service---Free sample and 24 hours on-line professional service and other requirements
Pharmaceutical Benzeneacetonitrile / Dipan / Diphenatrile / Diphenylacetonitrile CAS 86-29-3 Powder
Gw-0742 brief introduction
1. Name: GW-0742
2. Other Name: GW610742
3. CAS: 317318-84-6
4. Molecular Formula:C21H17F4NO3S2
5. Formula Weight:471.5
6. appearance:white solid
7. Mp:134.5-135.5 °C
8.Category:Sarm Steroid
GW-0742 Description:
1. GW0742 is a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice.
2. A high throughput screening campaign was conducted to identify small molecules with the ability to inhibit
3. the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator.
4. These inhibitors represent novel molecular probes to modulate gene regulation mediated by VDR. The peroxisome proliferator-activated receptor δ (PPARδ) agonist GW0742 was among the identified VDR-coactivator inhibitors and has been characterized herein as a pan nuclear receptor antagonist at concentrations higher than 12.1 µM.
5. The highest antagonist activity for GW0742 was found for VDR and the androgen receptor (AR). Surprisingly, GW0742 behaved as PPAR agonist/antagonist activating transcription at lower concentration and inhibiting this effect at higher concentrations.
6. A unique spectroscopic property of GW0742 was identified as well. In the presence of rhodamine-derived molecules, GW0742+ increased fluorescence intensity and fluorescence polarization at an excitation wavelength of 595 nm and emission wavelength of 615 nm in a dose dependent manner.
7. The GW0742-inhibited NR-coactivator binding resulted in a reduced expression of five different NR target genes in LNCaP cells in the presence of agonist. Especially VDR target genes CYP24A1, IGFBP-3 and TRPV6 were negatively regulated by GW0742.
8. GW0742 is the first VDR ligand inhibitor lacking the secosteroid structure of VDR ligand antagonists. Nevertheless, the VDR-meditated downstream process of cell differentiation was antagonized by GW0742 in HL-60 cells that were pretreated with the endogenous VDR agonist 1,25-dihydroxyvitamin D3.
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Product Name: | GW0742 / GW0742 |
CAS No.: | 317318-84-6 |
molecular formula: | C21H17F4NO3S2 |
Min. Order: | 10G |
Purity: | 99% |
Supply Ability: | 1000kg/month |
Application: | Chemical research |
Appearance: | White powder |
Package: | Aluminium foil bags |
Payment: | / MoneyGram/ Bitcoins/ TT |
Shipment: | EMS / EUB / USPS / UPS / TNT / FEDEX / DHL |
Product Name: GW0742
Other Name: GW610742
Purity: 99%min by HPLC
CAS No.: 317318-84-6
Appearance: White fine powder
Certificate: SGS,ISO,KOSHER,HALAL
GW0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.
GW0742 Basic information |
Product Name: | GW0742 |
Synonyms: | 2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW 0742X;GW 610742;GWdelta 0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylpheno;GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID |
CAS: | 317318-84-6 |
MF: | C21H17F4NO3S2 |
MW: | 471.49 |
EINECS: | |
Product Categories: | All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitor |
Mol File: | 317318-84-6.mol |
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