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Home > Products >  Manufacturer Direct Sales Low Price 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone CAS NO.32384-65-9

Manufacturer Direct Sales Low Price 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone CAS NO.32384-65-9 CAS NO.32384-65-9

  • FOB Price: USD: 1,900.00-2,000.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,MoneyGram
  • Available Specifications:

    AA(1-10)KilogramAA(1-50)KilogramA(1-50)Kilogram

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Keywords

  • 99%min 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
  • Hot sale 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
  • Buy High quality of 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

Quick Details

  • ProName: Manufacturer Direct Sales Low Price 2,...
  • CasNo: 32384-65-9
  • Molecular Formula: C18H42O6Si4
  • Appearance: white powder
  • Application: medical intermediate
  • DeliveryTime: 3-15 working days
  • PackAge: aluminium foil bag
  • Port: any port in China
  • ProductionCapacity: 1000 Kilogram/Week
  • Purity: 99%
  • Storage: dry and cool place
  • Transportation: by air or boat
  • LimitNum: 1 Kilogram
  • Moisture Content: 0
  • Impurity: 0
  • 0: 0

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(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Basic information
Description Reference
Product Name: (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
Synonyms: (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one;(3R,4S,5R,6R)-3,4,5-Tris[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydropyran-2-one;2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-2,3,4,6-Tetrakis-O-(trimethylsilyl)-gluconic acid delta-lactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, d-lactone;2,3,4,6-Tetrakis-O-triMethylsilyl-D-gluconolactoe;2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono1,5 lactone
CAS: 32384-65-9
MF: C18H42O6Si4
MW: 466.86448
EINECS: 1592732-453-0
Product Categories:  
Mol File: 32384-65-9.mol
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Structure
 
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Chemical Properties
Boiling point  417℃
density  0.97
Fp  171℃
 
 
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Usage And Synthesis
Description It is usually used as the intermediate and raw material in the chemistry synthesis and pharmaceutical industry. Especially, this chemical has been widely used in the design and synthesis of sodium-glucose transporter inhibitors.1 For example, this substance can be employed as raw material in the preparation of (1s)-1,5-anhydro-1-c-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol, which is commonly known as Dapagliflozin that act as the sodium dependent glucose transporters for treating type 2 diabetes.2 Moreover, it can also function as the intermediate for synthesizing empagliflozin, which is a novel and selective sodium glucose co-transporter-2 inhibitor.3 In addition, canagliflozin, another sodium glucose co-transporter-2 inhibitor, can be obtained by utilizing this substance as the intermediate.4
Reference
  1. Guo, C.; Hu, M.; DeOrazio, R. J.; Usyatinsky, A.; Fitzpatrick, K.; Zhang, Z. J.; Maeng, J. H.; Kitchen, D. B.; Tom, S.; Luche, M.; Khmelnitsky, Y.; Mhyre, A. J.; Guzzo, P. R.; Liu, S., The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg. Med. Chem. 2014, 22, 3414-3422.
  2. S Thirumalai Rajan; Eswaraiah, S., Process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol and its solvate thereof. US Patent 2015, WO 2015/132803 A2.
  3. Hrapchak, M.; Latli, B.; Wang, X. J.; Lee, H.; Campbell, S.; Song, J. J.; Senanayake, C. H., Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. J. Label. Compd. Radiopharm. 2014, 57, 687-694.
  4. Nomura, S.; Sakamaki, S.; Hongu, M.; Kawanishi, E.; Koga, Y.; Sakamoto, T.; Yamamoto, Y.; Ueta, K.; Kimata, H.; Nakayama, K.; Tsuda-Tsukimoto, M., Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. J. Med. Chem. 2010, 53, 6355-6360.
Chemical Properties Pale yellow oil

 

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Name  2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
 CAS NO.  32384-65-9

 Molecular Formula

  C18H42O6Si4
 Molecular Weight  466.86
 Appearance  light yellow liquid
 Purity  99% Min
 Density  0.97
 B.P.   417 ºC
 Flash Point  171 ºC
 
 
 
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Basic information
Product Name: (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
Synonyms: (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one;(3R,4S,5R,6R)-3,4,5-Tris[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydropyran-2-one;2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-2,3,4,6-Tetrakis-O-(trimethylsilyl)-gluconic acid delta-lactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, d-lactone;2,3,4,6-Tetrakis-O-triMethylsilyl-D-gluconolactoe;2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono1,5 lactone
CAS: 32384-65-9
MF: C18H42O6Si4
MW: 466.86448
EINECS:  
Product Categories:  
Mol File: 32384-65-9.mol
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Structure
 
(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one Chemical Properties
bp 417℃
density 0.97
Fp 171℃
 
 

 

 

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