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β-Nicotinamide Adenine Dinucleotide（NAD+) Basic Info:         

Product Name: B-Nicotinamide-Adenine Dinucleotide

Assay: 95%, 98%

CAS No: 53-84-9

Molecular Weight:C21H27N7O14P2 

Molecular Formula:663.4  

Appearance: White to yellowish powder

Storage: Store in cool & dry place, Keep away from strong light and heat.

Shelf Life: 24Months when properly stored.

Grade: Food grade/Medicine/Injection grade

Item	Specifications	Results
Assay(HPLC)	98.0%~102.0%	98.9%
Appearance	Off-white powder	Complies
Identification	IR	Complies
Melting point	156.0~160.0℃	157.0~158.0℃
Loss on drying	≤0.5%	0.11%
Residue on ignition	≤0.1%	0.06%
Related substance	≤1.0%	0.75%
Heavy metals	≤10ppm	Complies

 

 

What is β-Nicotinamide Adenine Dinucleotide（NAD+)

NAD,Nicotinamide adenine dinucleotide is a indispensable cofactor involved in several redox reactions in all forms of cellular life. It exists in two forms: an oxidized and reduced form abbreviated as NAD+ and NADH respectively.NAD+ is an oxidizing agent – it accepts electrons from other molecules and becomes reduced. This reaction forms NADH, which can then be used as a reducing agent to donate electrons.Both of these two stabilized form of NAD are marketed as a anti-age nutritional supplement, which is not under FDA regulation at the moment.

 

β-Nicotinamide Adenine Dinucleotide（NAD+) Benefit:

NAD+/NADH plays a significant role in the reactions associated with glycolysis, oxidative phosphorylation, and fermentation. Nicotinamide adenine dinucleotide(NAD) effects include the stimulation of dopamine, noradrenaline, and serotonin receptors, by which mechanism it is thought to increase mental alertness and clarity and improve concentration.

 

In the jet lag study, subjects who received NADH had significantly better cognitive performance and a trend toward reduced sleepiness on the first post-flight day than controls, and a smaller pilot study showed similar trends lasting through the second day. 

 

In 2000, Guarente's lab reported that NAD fuels the activity of sirtuins, including SIRT1—the more NAD there is in cells, the more SIRT1 does beneficial things. One of those things is to induce formation of new mitochondria. NAD can also activate another sirtuin, SIRT3, which is thought to keep mitochondria (Mitochondria are our cells' energy dynamos. Descended from bacteria that colonized other cells about 2 billion years, they get flaky as we age) running smoothly.

 

β-Nicotinamide Adenine Dinucleotide（NAD+) Function & Application:

Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as acoenzyme inredox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of thesecond messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. In addition to these metabolic functions, NAD+ emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, and can therefore have important extracellularroles.

 

The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. Drug design and drug development exploits NAD+ in three ways: as a direct target of drugs, by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by trying to inhibit NAD+biosynthesis.

 

The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer's andParkinson disease. Evidence on the benefit of NAD+ in neurodegeneration is mixed; some studies inmice have produced promising results whereas a placebo-controlled clinical trial in humans failed to show any effect.

 

NAD+ is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by Mycobacterium tuberculosis. Isoniazid is a prodrug and once it has entered the bacteria, it is activated by a peroxidase enzyme, which oxidizes the compound into a free radicalform. This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.

 

 

beta-Diphosphopyridine nucleotide Basic information

Product Name:	beta-Diphosphopyridine nucleotide
Synonyms:	OSTEOPONTIN, GST FUSION;)-1-beta-d-ribofuranosylpyridiniumhydroxide,innersalt;adenine-nicotinamidedinucleotide;adenosine5’-(trihydrogendiphosphate),p’.fwdarw.’-esterwith3-(aminocarbonyl;Adenosine5’-(trihydrogendiphosphate),P’.fwdarw.5’-esterwith3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium,innersalt;beta-diphosphopyridine;cozymasei;enzopride
CAS:	53-84-9
MF:	C21H27N7O14P2
MW:	663.43
EINECS:	200-184-4
Product Categories:	Bioproducts;Cofactor;Biochemistry;Enzymes and Coenzymes in Nucleic Acids;Nucleosides, Nucleotides & Related Reagents;Vitamin Related Compounds;Vitamins;nucleoside;Inhibitors
Mol File:	53-84-9.mol

beta-Diphosphopyridine nucleotide Chemical Properties

alpha	D20 -31.5° (c = 1.2 in water)
storage temp.	2-8°C
solubility	H2O: 50 mg/mL
form	Powder
color	White
PH	~3.0 (50mg/mL in water)
Water Solubility	Soluble in water at 50mg/ml
Merck	14,6344
Stability:	Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChIKey	BAWFJGJZGIEFAR-WWRWIPRPSA-N
EPA Substance Registry System	Adenosine 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.- D-ribofuranosylpyridinium, inner salt(53-84-9)

Safety Information

Hazard Codes	Xn,F,Xi
Risk Statements	36-68/20/21/22-20/21/22-40-22
Safety Statements	36-26-36/37-24/25
WGK Germany	3
RTECS	UU3450000
TSCA	Yes
HS Code	29349990

MSDS Information

Provider	Language
beta-NAD	English

beta-Diphosphopyridine nucleotide Usage And Synthesis

Chemical Properties	White powder
Uses	antidepressant, oxytocic
Uses	β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a c oenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleot ide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.

beta-Diphosphopyridine nucleotide Preparation Products And Raw materials

Raw materials

Ammonia-->Potassium chloride -->AMBERLITE(R) IRC-50-->Yeast extract-->Anion exchange resin,strong basic quarternary ammoniumⅠ-->Cation exchange resin,weak acidic acrylic acid-->Cation exchange resin,strong acidic styrene 001×7×7

 

 

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