China (Mainland)
Bosang factory supply High Quality Best Price Aniracetam 72432-10-1 CAS NO.72432-10-1
- FOB Price: USD: 1,900.00-2,000.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: T/T,MoneyGram
- Available Specifications:
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- Product Details
Keywords
- Aniracetam
- Brain Tonic Nootropic Aniracetam powder
- good supplier of Aniracetam
Quick Details
- ProName: Bosang factory supply High Quality Bes...
- CasNo: 72432-10-1
- Molecular Formula: C12H13NO3
- Appearance: white powder
- Application: medical intermediate
- DeliveryTime: 3-15 working days
- PackAge: aluminium foil bag
- Port: any port in China
- ProductionCapacity: 1000 Kilogram/Week
- Purity: 99%
- Storage: dry and cool place
- Transportation: by air or boat
- LimitNum: 1 Kilogram
- Moisture Content: 0
- Impurity: 0
- 0: 0
Superiority
Our advantages
1, Rich Experience in produce----We have 26 years experiences in chemical products and 6years experiences in Pharmaceutical Intermediate products and APIS.
2, Competitive price ---We have the competitive price owing to low labor cos,t(we need large quantity).
3, Stable supply ability ---We have a stable supply ability owing to three workshops produce plan every month and stock plan for each products ;
4, Shipment Timely---The shipment never delayed and we can get reorder from new customer;
5, Rich experience in sales-- We have rich experience working with large international company.
6, Strong Quality Control System ---We have a very strong quality control system Raw material control / process control/ finished product quality inspection.
7. We Supply the Technology Support for Analyze and Synthesis and do new product according to customer's requirement.
8. Accept third lab test---We accept audit directly and tested . No any risk commitment for Customers.
9.Various payment terms---We can accept various payment terms include TT, and so on.
10,Our service---Free sample and 24 hours on-line professional service and other requirements
Aniracetam Basic Info:
Product name: Aniracetam
Cas no.:72432-10-1
Synonyms:1-p-anisoyl-2-pyrrolidinone; ampamet;aniracetam;1-(4-methoxybenzoyl)pyrrolidin-2-one;ro 13-5057;draganon;1-anisoyl-2-pyrrolidinone; sarpul;1-(4-methoxybenzoyl)-2-pyrrolidinone;
Molecular formula: c12h13no3
Molecular weight: 219.23700
Appearance: white crystalline or crystalline powder
Density: 1.236 g/cm3
Melting point: 119-122ºc
Boiling point: 399.7ºc at 760 mmhg
Flash point: 195.5ºc
Refractive index: 1.573
Specification: 99% by HPLC
| Item | Specifications | Results |
| Assay(HPLC) | 98.0%~102.0% | 98.9% |
| Appearance | Off-white crystalline powder | Complies |
| Identification | IR | Complies |
| Melting point | 156.0~160.0℃ | 157.0~158.0℃ |
| Loss on drying | ≤0.5% | 0.11% |
| Residue on ignition | ≤0.1% | 0.06% |
| Related substance | ≤1.0% | 0.75% |
| Heavy metals | ≤10ppm | Complies |
Details
Welcome to Hebei Bosang International Trade Co.,Ltd.
Hebei Bosang International Trade Co.,Ltd. specializes in exporting high quality Pharmaceutical intermediates，Pharmaceutical raw materials，Phenylephrine，Safe Organic Solvents,HGH, Plant Extract, Spice Auxiliary and Hormones.
Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection. We earned customer trust and created a good reputation during these years.
Our company is always adhering to the ""open, flexible; integrity, and win-win"" business purposes and under the guidance of Business philosophy: "keeping credit, value quality, punctual delivery, favorable price “, continuously developing the excellent products, improving the service quality, putting efforts to expand the international market, we are committed to provide the excellent quality of products and the perfect services to the friends all over the world. We welcome all merchants to visit our company and talk over business with us!
We will provide the most comprehensive products and service to you! We are looking forward to your cooperation.
Aniracetam Quick details
Chemical Name: Aniracetam
CAS No.:72432-10-1
Molecular Formula:C12H13NO3
Molecular weight: 219.24
Appearance: white powder
Aniracetam Specification
|
Item |
Specification |
|
Appearance |
White crystalline powder |
|
Identification |
Must positive |
|
Melting point |
119°C ~122°C |
|
Absorbance |
476~506 |
|
Chlorides |
≤0.014% |
|
Sulfate |
≤0.04% |
|
Loss on drying |
<0.5% |
|
Related substances |
<1.0% |
|
Sulfated ash |
<0.1% |
|
Heavy metals |
≤20ppm |
|
Assay by HPLC |
≥95.0%
|
Pure Aniracetam 99%,CAS No.72432-10-1,supply Aniracetam
|
tems |
Specifications |
Results |
|
Appearance |
White crystalline powder |
Complies |
|
Melting point |
119-122°C |
120.2~121.1°C |
|
Absorbance |
476-506 |
489 |
|
Chlorides |
0.014% |
Complies |
|
Sulfates |
0.04% |
Complies |
|
Loss on drying |
≤0.5% |
0.40% |
|
Related substances |
≤1.0% |
0.38% |
|
Sulfated ash |
<0.1% |
0.05% |
|
Heavy metals |
<20ppm |
Complies |
|
Assay |
98.0-101.0% |
99.35% |
|
Item |
Specification |
|
Appearance |
White crystalline powder |
|
Identification |
Must positive |
|
Melting point |
119°C ~122°C |
|
Absorbance |
476~506 |
|
Chlorides |
≤0.014% |
|
Sulfate |
≤0.04% |
|
Loss on drying |
<0.5% |
|
Related substances |
<1.0% |
|
Sulfated ash |
<0.1% |
|
Heavy metals |
≤20ppm |
|
Assay by HPLC |
≥95.0% |
| Aniracetam Basic information |
| Pharmacological effects Pharmacokinetics Chemical Properties Application Production methods |
| Product Name: | Aniracetam |
| Synonyms: | 1-(4-methoxybenzoyl)-2-pyrrolidinon;1-(p-methoxybenzoyl)-2-pyrrolidinon;1-p-anisoyl-2-pyrrolidinone;draganon;sarpul;1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE;ANIRACETAM;RO 13-5057 |
| CAS: | 72432-10-1 |
| MF: | C12H13NO3 |
| MW: | 219.24 |
| EINECS: | |
| Product Categories: | Glutamate;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Smart drug;Nootropic |
| Mol File: | 72432-10-1.mol |
| Aniracetam Chemical Properties |
| mp | 121-122 C |
| storage temp. | Store at RT |
| CAS DataBase Reference | 72432-10-1(CAS DataBase Reference) |
| Safety Information |
| WGK Germany | 2 |
| RTECS | UY5781900 |
| MSDS Information |
| Provider | Language |
|---|---|
| 1-(4-Methoxybenzoyl)-2-pyrrolidinone | English |
| SigmaAldrich | English |
| Aniracetam Usage And Synthesis |
| Levetiracetam class brain cell metabolism drugs | Aniracetam, also known as aniracetam, together with piracetam and nefiracetam, belong to the same class of piracetam metabolized drugs of brain cells. These drugs can enhance the activity of synaptic neurons phospholipase, increase the ATP formation and transport in brain, increase protein synthesis and RNA, promote the usage of brain on amino acids, phospholipids, glucose and oxygen, increase the patient's response, excitability and memory. Aniracetam has a higher effect than piracetam, but with a relatively minor side effect. |
| Pharmacological effects | Aniracetam, a cyclized derivative of γ- aminobutyric acid, can improve the brain function. It can selectively exert effect on central nervous system through penetration into blood-brain barrier. It can activate the metabolism activity of brain cell and protect the nerve cells. This product can also promote the intelligence by affecting the glutamate receptor system. Moreover, it improves skin’s resistance to hypoxia, preventing the occurrence of malfunction of learning and memory caused by a variety of chemical substances, hypercapnia, scopolamine and electrical shock. This product has no sedative or excitation effect. Animal experiments show that this product promotes the memory recovery in normal rats’ learning process. It can fight against hypoxia-induced memory recession and relieve the memory malfunction caused by certain reasons. [Indications] It is used for the treatment of mild or moderate malfunction of learning, memory and cognition in vascular dementia and Alzheimer's disease. It can also be used for treating memory recession after stroke, memory defect in old people and children who undergo development retardation. The above information is edited by the Chemicalbook of Dai Xiongfeng. |
| Pharmacokinetics | According to literature, it is rapidly absorbed after oral administration by rats. The plasma concentration reaches highest level within 20 to 40 minutes. The drug is mainly distributed in the gastrointestinal tract, kidney, liver, brain and blood. After 24 hours, 77% to 85% is excreted out through urine, 4% from faeces. Major metabolite in urine is N-p-anisoyl-aminobutyric acid and 5-hydroxy-2-pyrrolidone. Human: After oral administration, half-life of blood Plains drug elimination averages at 20 to 30 minutes. Plasma concentration becomes undetectable after two hours. |
| Adverse reactions | This product has fewer adverse reactions, occasionally dry mouth, anorexia, constipation, dizziness, and drowsiness. They disappear after stopping taking the drug. |
| Precautions | 1. Adjust the dose for patients of liver dysfunction. 2. It can deteriorate the symptoms of Huntington's chorea. 3. Patients who is allergic to this drug or other pyrrolidone-class drugs are not allowed. 4. Safety range: 0.3 ~ 1.8g / d. |
| Chemical Properties | Crystallization from ethanol, m.p. 12l ~ 122 °C. Acute toxicity LD50 for rat, mouse (mg / kg): 4500,> 5000 oral. |
| Application | 1. Piracetam derivative, a improvement agent for γ-lactam brain function. Selectively exert effect on the brain system, promote and enhance memory function. Compared with Piracetam, it has a stronger effect, faster onset of action, and lower toxicity. Used for improving brain function, especially treating the behavioral and mental disorders for sequela patients of senile dementia, cerebrovascular disease. 2. It is a γ-lactam-class agent of improving brain function. It can exert on the brain tissue through penetrating the blood-brain barrier, and improve brain function and memory. |
| Production methods | Method 1: Reflux the reaction mixture of 2- pyrrolidone and methoxy benzoyl chloride at 0～10 °C in ether and in the presence of triethylamine for three hours to get the Aniracetam. Method 2: Perform the reaction between p-methoxy benzoic acid and thionyl chloride to get the methoxy benzoyl chloride (yield 90%). Then perform the reaction between methoxybenzoyl chloride and 4-aminobutyric acid in an aqueous solution of sodium hydroxide and in the presence of benzyl triethyl ammonium salt (of TEBA) to get 4- (4-methoxybenzoyl) amino butyric acid (yield 69.4%). Then have cyclization reaction in the presence of toluene and thionyl chloride to get aniracetam, yield 80.4%, mp 118 ~ 120 °C. Method 3: Methoxybenzoic acid is chloridized as post-methoxy benzoyl chloride first. Then it is reacted together with Sodium 2-pyrrolidone in tetrahydrofuran and 4-dimethylaminopyridine (DMAP) to obtain the aniracetam yield 76.2% (Take account of p-methoxy benzoyl chloride), the melting point of 118 ~ 119 °C. Method 4: 2-pyrrolidone was refluxed 1 hour in toluene containing sodium methoxide first. Then methanol was totally evaporated. Add TEBA at 10 °C, Titrate a toluene solution of p-anisoyl chloride and stir them at room temperature for 0.5h. Then stirred at 50 °C for 6h to obtain the aniracetam of 85% yield (take account of 2-pyrrolidone), melting point 120 ~ 121 °C. Method 5: 2-pyrrolidinone and triethylamine is mixed at 0 ~ 10 °C first. Then perform titration of chlorotrimethylsilane for 2 h reaction at room temperature. Add the dioxane solution of Methoxybenzoyl chloride and stir 2h at 40 °C to obtain aniracetam, yield 65%. |
| Chemical Properties | Crystalline Solid |
| Usage | cognitive enhancer |
| Usage | Cognition enhancer related to Piracetam. Nootropic. |
| Biological Activity | Nootropic, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration. |
Market :
Our Service
We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.
we will try our best to satisfied you:
1. Tailor-made for every customers.
2. Third-party test for the products you demand.
3. Test your counter-samples and produce them for you.
4. Best discount for old customers.
5.24 hours service.
payment way:
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any question you can feel free to contact with us
Packing&Delivery
Package:20Kg Paper box or 25kg Paper barrel
|
By Courier |
By Air |
By Sea |
|
≤50kg |
50kg-500kg |
≥500kgs |
|
3-7 Days |
5-7 Days |
15-40Days |
|
Door to Door |
Airport to Airport |
Seaport to Seaport |
|
Easy to get products |
Need do custom clearance |
Need do custom clearance
|