China (Mainland)
99% High Purity And Top Quality Afatinib 850140-72-6 With Reasonable Price CAS NO.850140-72-6
- FOB Price: USD: 1,900.00-2,000.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: T/T,MoneyGram
- Available Specifications:
AA(1-10)KilogramAA(1-50)KilogramA(1-50)Kilogram
- Product Details
Keywords
- BIBW 2992; BIBW-2992
- Competitive price/ Top quality of Afatinib
- Afatinib Exporter in China
Quick Details
- ProName: 99% High Purity And Top Quality Afatin...
- CasNo: 850140-72-6
- Molecular Formula: C24H25ClFN5O3
- Appearance: white powder
- Application: medical intermediate
- DeliveryTime: 3-15 working days
- PackAge: aluminium foil bag
- Port: any port in China
- ProductionCapacity: 1000 Kilogram/Week
- Purity: 99%
- Storage: dry and cool place
- Transportation: by air or boat
- LimitNum: 1 Kilogram
- Moisture Content: 0
- Impurity: 0
- 0: 0
Superiority
Our advantages
1, Rich Experience in produce----We have 26 years experiences in chemical products and 6years experiences in Pharmaceutical Intermediate products and APIS.
2, Competitive price ---We have the competitive price owing to low labor cos,t(we need large quantity).
3, Stable supply ability ---We have a stable supply ability owing to three workshops produce plan every month and stock plan for each products ;
4, Shipment Timely---The shipment never delayed and we can get reorder from new customer;
5, Rich experience in sales-- We have rich experience working with large international company.
6, Strong Quality Control System ---We have a very strong quality control system Raw material control / process control/ finished product quality inspection.
7. We Supply the Technology Support for Analyze and Synthesis and do new product according to customer's requirement.
8. Accept third lab test---We accept audit directly and tested . No any risk commitment for Customers.
9.Various payment terms---We can accept various payment terms include TT,,BTC and so on.
10,Our service---Free sample and 24 hours on-line professional service and other requirements
Afatinib
Afatinib Brief Description
CAS No.:850140-72-6
MF:C24H25ClFN5O3
MW:485.9384032
Competitive price with high quality
Conforms to BP/USP/EP/FCC
Afatinib COA
|
ITEM |
STANDARD |
RESULTS |
|
Appearance |
Off-white powder |
Off-white powder |
|
Identification |
HPLC ,NMR |
Complies |
|
Residue on Ignition |
≤0.10% |
0.05% |
|
Loss on Drying |
≤0.50% |
0.15% |
|
Heavy Metal |
≤20ppm |
<20ppm |
|
Purity(HPLC) |
≥99.0% |
99.99% |
|
Conclusion |
It complies with Enterprise Standard |
|
Details
Welcome to Hebei Bosang International Trade Co.,Ltd.
Hebei Bosang International Trade Co.,Ltd. specializes in exporting high quality Pharmaceutical intermediates，Pharmaceutical raw materials，Phenylephrine，Safe Organic Solvents,HGH, Plant Extract, Spice Auxiliary and Hormones.
Our company is always adhering to the ""open, flexible; integrity, and win-win"" business purposes and under the guidance of Business philosophy: "keeping credit, value quality, punctual delivery, favorable price “, continuously developing the excellent products, improving the service quality, putting efforts to expand the international market, we are committed to provide the excellent quality of products and the perfect services to the friends all over the world. We welcome all merchants to visit our company and talk over business with us!
|
product name |
Afatinib | |
|
assay |
99.0% to 101.0% |
99.9% |
|
melting point |
---- |
---- |
|
loss on drying |
0.5%max. |
0.22% |
|
sulphated ash |
0.1%max. |
0.05% |
|
acidity |
0.01m naoh<0.50ml |
0.39 |
Function
Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation TKIs like erlotinib or gefitinib, but also against mutations such as T790M which are not sensitive to these standard therapies.Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.
Application
It has received regulatory approval for use as a treatment for non-small cell lung cancer, although there is emerging evidence to support its use in other cancers such as breast cancer.
Specification
|
Product Name |
Afatinib |
|
|
TEST |
SPECIFICATION |
RESULT |
|
Character |
White to off-white powder |
White powder |
|
Identification |
A. Infrared absorption B. The retention time of major peak of sample corresponds to that of reference standard |
Conforms
Conforms
|
|
Loss on drying |
≤0.5% |
0.22% |
|
Residue on Ignition |
≤0.1% |
0.03% |
|
Related compounds |
Impurity A≤0.2% Impurity B≤0.3% Impurity C≤1.0% Any other impurity≤1.0% |
0.02% 0.04% 0.06% 0.04% |
|
Residual Solvents |
Methanol≤0.3% Acetonum≤0.5% Methylenc dichloride≤0.06% MTBE≤0.5% Ethyl acetate≤0.5% Methylbenzene≤0.089% |
ND ND ND ND 0.12% ND |
|
Assay |
97.0%~101.5% C16H16CINO2S.H2SO4 (calculated on the dried basis) |
99.11% |
|
Packaging and storage |
Preserve in well-closed containers, and store at controlled room temperature. |
|
|
Conclusion |
All the results conform to the requirement of USP34. |
|
Packaging
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery
Usually within3-5 working days after full payment.
Shipping
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
| Afatinib Basic information |
| Product Name: | Afatinib |
| Synonyms: | Afatinib;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;4-[(3-chloro-4-fluorophenyl)aMino]-6-{[4-(N,N-diMethylaMino)-1-oxo-2-buten-1-yl]aMino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dime;Afatinib API;Afatinib(BIBW2992MA2);Afatinib (with 1 int.) |
| CAS: | 850140-72-6 |
| MF: | C24H25ClFN5O3 |
| MW: | 485.9384032 |
| EINECS: | |
| Product Categories: | Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;tyrosine kinase receptor inhibitor;Antineoplastic |
| Mol File: | 850140-72-6.mol |
|
|
|
| Afatinib Chemical Properties |
| density | 1.380 |
| Safety Information |
| Afatinib Usage And Synthesis |
| Usage | An aminocrotonylamino-substituted quinazoline derivative |
Market :
Our Service
We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.
we will try our best to satisfied you:
1. Tailor-made for every customers.
2. Third-party test for the products you demand.
3. Test your counter-samples and produce them for you.
4. Best discount for old customers.
5.24 hours service.
payment way:
,moneygram ,T/T,btc ,and so on,
any question you can feel free to contact with us
Packing&Delivery
Package:20Kg Paper box or 25kg Paper barrel
|
By Courier |
By Air |
By Sea |
|
≤50kg |
50kg-500kg |
≥500kgs |
|
3-7 Days |
5-7 Days |
15-40Days |
|
Door to Door |
Airport to Airport |
Seaport to Seaport |
|
Easy to get products |
Need do custom clearance |
Need do custom clearance
|