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Home > Products >  High quality Alogliptin benzoate Cas 850649-62-6 with best price and good service

High quality Alogliptin benzoate Cas 850649-62-6 with best price and good service CAS NO.850649-62-6

  • FOB Price: USD: 1,900.00-2,000.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,MoneyGram
  • Available Specifications:

    AA(1-10)KilogramAA(1-50)KilogramA(1-50)Kilogram

  • Product Details

Keywords

  • Alogliptin benzoate manufacturer
  • Alogliptin benzoate low price
  • Alogliptin benzoate high quality

Quick Details

  • ProName: High quality Alogliptin benzoate Cas 8...
  • CasNo: 850649-62-6
  • Molecular Formula: C18H21N5O2.C7H6O2
  • Appearance: white powder
  • Application: medical intermediate
  • DeliveryTime: 3-15 working days
  • PackAge: aluminium foil bag
  • Port: any port in China
  • ProductionCapacity: 1000 Kilogram/Week
  • Purity: 99%
  • Storage: dry and cool place
  • Transportation: by air or boat
  • LimitNum: 1 Kilogram
  • Moisture Content: 0
  • Impurity: 0
  • 0: 0

Superiority

Our advantages

1, Rich Experience in produce----We have 26 years experiences in chemical products and 6years experiences in Pharmaceutical Intermediate products and APIS.

2, Competitive price ---We have the competitive price owing to low labor cos,t(we need large quantity).

3, Stable supply ability ---We have a stable supply ability owing to three workshops produce plan every month and stock plan for each products ;

4, Shipment Timely---The shipment never delayed and we can get reorder from new customer;

5, Rich experience in sales-- We have rich experience working with large international company.

6, Strong Quality Control System ---We have a very strong quality control system Raw material control / process control/ finished product quality inspection.

7. We Supply the Technology Support for Analyze and Synthesis and do new product according to customer's requirement.

8. Accept third lab test---We accept audit directly and tested . No any risk commitment for Customers.

9.Various payment terms---We can accept various payment terms include  TT,,BTC and so on.

10,Our service---Free sample and 24 hours on-line professional service and other requirements

High quality Alogliptin benzoate Cas 850649-62-6 with best price and good service

 



Specification

 

Items

 

Specification

 

Result

Assay

99%

99.6%

Appearance

White crystalline powder

White crystalline powder

Loss on drying

0.5%

0.2%

Heavy metals

10ppm

<10ppm

 

Details

Welcome to Hebei Bosang International Trade Co.,Ltd.

 

Hebei Bosang International Trade Co.,Ltd. specializes in exporting high quality Pharmaceutical intermediates,Pharmaceutical raw materials,Phenylephrine,Safe Organic Solvents,HGH, Plant Extract, Spice Auxiliary and Hormones.

Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meet the requirements of security and environmental protection. We earned customer trust and created a good reputation during these years.

Our company is always adhering to the ""open, flexible; integrity, and win-win"" business purposes and under the guidance of Business philosophy: "keeping credit, value quality, punctual delivery, favorable price “, continuously developing the excellent products, improving the service quality, putting efforts to expand the international market, we are committed to provide the excellent quality of products and the perfect services to the friends all over the world. We welcome all merchants to visit our company and talk over business with us!

 

We will provide the most comprehensive products and service to you! We are looking forward to your cooperation.
 

Product information

 
 
Alogliptin benzoate Basic information
Pharmacological effects Detection method - high performance liquid chromatography (HPLC) method Pharmacokinetics Safety Alogliptin benzoate compound medicines
Product Name: Alogliptin benzoate
Synonyms: ALOGLIPTIN BENZOATE;2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile benzoate;2-[[6-[(3R)-3-aMino-1-piperidinyl]-3,4-dihydro-3-Methyl-2,4-dioxo-1(2H)-pyriMidinyl]Methyl]-Benzonitrile Monobenzoate;SYR 322;Nesina;2-[6-[3(R)-AMinopiperidin-1-yl]-3-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-ylMethyl]benzonitrile benzoate;(R)-2-((6-(3-aMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)benzonitrile benzoate;2-[6-[3(R)-AMinopiperidin-1-yl]-3-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-ylMethyl]benzonitrile benzoate Monobenzoate
CAS: 850649-62-6
MF: C18H21N5O2.C7H6O2
MW: 461.519
EINECS:  
Product Categories: Final material;Inhibitors
Mol File: 850649-62-6.mol
Alogliptin benzoate Structure
 
Alogliptin benzoate Usage And Synthesis
Type 2 diabetes drugs Alogliptin benzoate is a kind of serine protease dipeptidyl peptidase IV (DPP-IV) inhibitor developed by the Takeda Company (Japan). This product can maintain the in vivo level of glucagon-like (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) levels, stimulating the secretion of insulin, and thus playing a hypoglycemic effect. A randomized, placebo-controlled clinical trial results have showed that compared to placebo, the Alogliptin monotherapy can significantly improve the glycemic control in patients with type 2 diabetes without increasing the incidence of hypoglycemia as well as with a good tolerance. Alogliptin and its pharmaceutical composition are orally effective specific DPP-IV inhibitor following the emergence of sitagliptin and vildagliptin, providing a new and important treatment option for type 2 diabetes patients and have a wide range of application prospects. Alogliptin benzoate is officially marketed at the beginning of 2014, and is the first batch of type 2 diabetes drugs with confirmed cardiovascular safety approve in China, providing more and better choices for the treatment of type 2 diabetes.
Pharmacological effects Incretin is the postprandial peptide hormone produced in gastrointestinal tract and can promote the islet β cells to secrete insulin. It includes glucagon-like peptide -1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), secreted by the L cells in the ileum and colon and K cells in the duodenum, respectively. GLP-1 and GIP, as an active hormone, can be released into the blood circulation within a few minutes after food intake and further quickly degraded and inactivated by serine protease DPP-4. The in vivo postprandial incretin levels of patients of type 2 diabetes was significantly reduced, thereby preventing the inactivation of incretin to increase the duration of action for effectively lowering blood sugar. Alogliptin benzoate, as a kind of DPP-4 inhibitors, can increase the in vivo GLP-1 level via selective inhibition of DPP-4 and reduction of the inactivation of GLP-1, and thus reducing blood sugar. When the blood sugar to normal levels, they will not continue to play a hypoglycemic effect, so it can also effectively reduce the risk of hypoglycemia. Additionally, DPP-4 inhibitors can also delay gastric emptying and increase satiety, suppress appetite, and help the patients lose weight. Therefore, these drugs, while effectively reducing the blood sugar, can also reduce the risk of hypoglycemia and weight gain, further overcoming the obstacles for patients to reach standard indicators levels , bringing new hope for the treatment of diabetes.
Synthetic method (1) Take 6-chloro-3-methyl uracil as a starting material; it has the alkylation reaction with 2-bromomethyl-benzonitrile under alkaline conditions, and further has substitution reaction with (R) -3- aminopiperidine di-hydrochloride to give (R) -2 - [(6- (3- amino-piperidin-1-yl) -3-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1 ( 2H)-yl) methyl] benzonitrile (A01), and then obtain the alogliptin benzoate salt through reaction with benzoic acid. This method has a total absorption rate being 56.1% with many advantages such as easy available raw materials, mild reaction condition, high purity product, less kinds of reagent, etc., This method is more suitable for industrial production.
Synthetic roadmap of alogliptin benzoate with 3-methyl-6-chloro-uracil as the raw material

 

 

 

 

Market : 

 

Our Service

We offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.

we will try our best to satisfied you:

1. Tailor-made for every customers. 

2. Third-party test for the products you demand. 

3. Test your counter-samples and produce them for you. 

4. Best discount for old customers. 

5.24 hours service.

payment way:

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any question you can feel free to contact with us 

Packing&Delivery

Package:20Kg Paper box or 25kg Paper barrel

By Courier

By Air

By Sea

≤50kg

50kg-500kg

≥500kgs

3-7 Days

5-7 Days

15-40Days

 Door to Door

Airport to Airport

Seaport to Seaport

 Easy to get products

Need do custom clearance

Need do custom clearance

 

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